Market Intelligence Report
What Users Experience, What Science Shows, Where the Opportunities Lie
The GLP-1 receptor agonist market represents a once-in-a-generation opportunity for the supplement and functional ingredient industry. With millions of consumers actively seeking solutions to support their medication journey—or alternatives to it—this report synthesizes three data streams to identify actionable opportunities.
2.9M
Monthly Google Searches for Core GLP-1 Terms
674K
Monthly Amazon Searches for GLP-1 Products
+397%
Year-over-Year Growth Since Late 2023
The Bottom Line
Consumers on GLP-1s face predictable, well-documented challenges at specific points in their journey. The search data quantifies demand for solutions. The clinical literature validates the problems. The supplement industry is positioned to fill significant gaps.
690 Google keywords, 100+ Amazon keywords, TikTok trends revealing real-time consumer demand
PubMed studies validating which consumer concerns are medically substantiated
Social media insights showing lived experience across the treatment timeline
| Platform | Monthly Search Volume | YoY Trend |
|---|---|---|
| Google – Core GLP-1 terms | 2,905,000 | +397% |
| Google – "GLP-1" exact match | 1,220,000 | +397% |
| Amazon – "GLP1" products | 674,000 | +172% |
| TikTok – "GLP1" | 996,000 | +172% |
Deep analysis of keyword data reveals six distinct consumer need states, each representing a product development or positioning opportunity.
Consumers desperately want non-injection options. This represents the single largest emerging search category.
| Search Term | Monthly Volume | Trend |
|---|---|---|
| glp 1 patches | 201,000 | +401,900% |
| do glp 1 patches work | 18,100 | +180,900% |
| glp 1 patches reviews | 27,100 | +1,297% |
| glp 1 pills | 49,500 | +3,795% |
| oral glp 1 | 18,100 | +1,594% |
Amazon echo: "GLP 1 patches" draws 90,300 monthly searches on Amazon—consumers are actively shopping, not just researching.
Opportunity
While actual GLP-1 patches don't exist in prescription form, consumers are searching for transdermal or alternative delivery mechanisms. Products positioned as "GLP-1 support patches" or topical formulations are capturing this intent.
Concerns about side effects and long-term safety are growing faster than general interest in the medications.
| Search Term | Monthly Volume | Trend |
|---|---|---|
| glp 1 side effects | 74,000 | +1,258% |
| is glp 1 safe | 8,100 | +5,592% |
| are glp 1 safe | 1,900 | +7,100% |
| does glp 1 cause hair loss | 1,900 | +10,700% |
| long term effects of glp 1 | 1,600 | +3,122% |
Clinical Validation
A 2025 review in Biomedicines found that GI adverse effects are reported in 65-84% of patients treated with liraglutide, semaglutide, or tirzepatide.
A 2025 review in Mayo Clinic Proceedings recommends: "dietary modifications—smaller, more frequent meals; adequate hydration; and avoidance of high-fat or high-sugar foods."
Opportunity
Digestive support formulations specifically designed for the GLP-1 population. Products addressing nausea, constipation, and GI discomfort during the dose escalation phase (weeks 1-8) when symptoms peak.
This concern has crossed from curiosity to active product seeking.
| Platform | Search Term | Monthly Volume | Trend |
|---|---|---|---|
| does glp 1 cause hair loss | 1,900 | +10,700% | |
| Amazon | glp-1 hair loss | 2,000 | +1,100% |
| Amazon | glp 1 hair loss supplement | 90 | +1,000% |
Clinical Validation
A 2025 review in Skin Appendage Disorders confirms that hair loss, "particularly in the form of telogen effluvium, has been observed, potentially linked to rapid weight loss from GLP-1RA use" rather than a direct drug effect.
User Voice
"Are there any side effects of taking both? Can you experience hair loss? I began losing large amounts of hair and stopped the GLP-1 four months in. I am now only on HRT and 4 months out still losing so much hair."
Opportunity
Hair, skin, and nail formulations positioned for the rapid weight loss population. Biotin, collagen, and keratin products with messaging around "supporting your body during transformation."
Financial barriers are creating a desperate search for affordable access.
| Search Term | Monthly Volume | Trend |
|---|---|---|
| cheapest glp 1 without insurance | 5,400 | +60,400% |
| cheap glp 1 | 8,100 | +1,951% |
| cheapest glp 1 online | 5,400 | +4,809% |
| goodrx glp 1 | 1,600 | +5,233% |
| costco glp 1 | 2,900 | +1,963% |
User Voices
"Lucky! My doctor prescribed GLP-1 shots, but I'm self-pay for $499 a month."
"There is a directory of high quality and highly reviewed GLP-1 telehealth providers... which only charge $200-300/month."
Opportunity
Natural GLP-1 "booster" supplements positioned as adjuncts or alternatives. Products that help users maintain results on lower medication doses. Supplements for the maintenance phase that might reduce medication dependence.
Consumers are actively seeking non-pharmaceutical options to stimulate endogenous GLP-1.
| Search Term | Monthly Volume | Trend |
|---|---|---|
| natural glp 1 | 27,100 | +834% |
| natural glp 1 foods | 3,600 | +3,900% |
| supplements that increase glp 1 | 4,400 | +230% |
| natural glp 1 supplement | 4,400 | +1,275% |
| berberine glp 1 | 1,300 | +156% |
| moringa glp 1 | 880 | +700% |
Clinical Validation
A 2025 review in Diabetes Research and Clinical Practice found that prebiotic oligosaccharides "selectively stimulate beneficial gut microbiota... leading to the production of short-chain fatty acids (SCFAs)... These SCFAs play a pivotal role in enhancing the release of gut hormones such as GLP-1."
A 2025 study in Food Research International demonstrated that dietary fibers from Moringa leaves "remarkably promoted the secretion of glucagon-like peptide-1 (GLP-1)."
Opportunity
Fiber-based and prebiotic formulations with clinical substantiation for GLP-1 stimulation. The science is catching up to consumer demand.
Branded products are already capturing significant search volume.
| Brand/Product | Google Monthly | Amazon Monthly | Trend |
|---|---|---|---|
| Lemme GLP-1 | 22,200 | — | -87% (declining) |
| Pendulum GLP-1 probiotic | 9,900 | — | Emerging |
| Supergut GLP-1 booster | 4,400 | — | Stable |
| ColonBroom GLP-1 booster | 2,400 | — | +4,614% |
| Nature Made GLP-1 companion | — | 320 | +8,400% |
| Bioma GLP-1 booster | — | 90 | +500% |
The Lesson
First-movers in branded GLP-1 support products are capturing search demand. The ColonBroom growth (+4,614%) shows the category is still nascent with room for new entrants.
The search data tells us what people want. User testimonials reveal when they want it. Clinical research validates why they need it.
Days 1-7: The Food Noise Stops
User Experience
"I'm only on day 4 using Zepbound and must say the 'food noise' is much less now."
"It's my first week on GLP-1, I have been eating healthy and going to the gym at least 3 times a week—already down 8 pounds."
But also...
"It's my 3rd week on 1mg of Ozempic for weight loss and there are times I feel hungry, full, and nauseous at the same time. Is this normal?"
Supplement Opportunities
Weeks 2-8: The Adaptation Period
User Experience
"My 3rd week on tirzepatide, and definitely eating much is the most discomforting thing to do while using GLP-1 drugs."
"I've been on GLP-1 for 5 weeks and there is no way a microdose for 90 days would help me. I don't really notice a difference in my appetite at the lowest regular doses."
The Constipation Reality
Constipation is among the most common GI adverse effects. The Mayo Clinic Proceedings review notes management includes "dietary modifications" and "supportive medications."
Supplement Opportunities
Months 2-6: The Transformation Zone
User Experience
"Two months on GLP-1s while also continuing everything I was already doing, and I lost 30lbs. I literally cried for over an hour seeing the scale numbers because it finally gave me validation after working myself to the bone for nearly a full year."
"In 6 months, I have lost 45 pounds, 33 inches overall, and dropped 3 clothing sizes. An unexpected bonus: my IBS of many years is completely gone!"
But muscle loss emerges as a concern...
"The big debate right now is GLP-1s and muscle wasting. On the anti side, they'll tell you that GLP-1s are shown to cause muscle atrophy, and, for people of advanced ages, this is muscle that they most likely will never get back."
Supplement Opportunities
Months 6-12+: Maintenance and the Discontinuation Question
User Experience
"I've lowered the dose of my GLP-1 meds as I hit my goal weight. Eating the same amount. Exercising more. The result? Weight is slowly creeping on again. The drugs are doing something to my body that diet and exercise alone isn't."
"Used GLP-1s and went from a BMI of 38 to 27. Haven't taken it the past 5 months and maintained that loss easily."
"I don't believe that you can't wean yourself off the GLP-1 drugs, I did and have friends that have too."
Supplement Opportunities
A 2024 review in Obesity Reviews quantified the muscle loss problem: clinical trial participants receiving GLP-1s for obesity lost 10% or more of their muscle mass during the 68- to 72-week interventions—approximately equivalent to 20 years of age-related muscle loss.
Protein Target
>1.2 g/kg/day
evenly distributed across meals
Expert Recommendation
"Oral nutritional supplements" explicitly mentioned in clinical guidance
Search data reveals an emerging user-driven trend—users experimenting with lower doses and extended intervals to reduce costs and side effects while maintaining benefits.
27,100
Monthly searches "microdosing glp 1"
+54,900%
Growth from zero baseline
64.8%
One-year discontinuation rate
Clinical context: The STEP 1 extension study found participants who stopped semaglutide "regained two-thirds of their prior weight loss." This creates strong demand for maintenance support products.
A particularly compelling area of emerging research supports probiotic and prebiotic interventions as GLP-1 adjuncts.
2025 Randomized Controlled Trial (Hormones Journal)
Tested dulaglutide combined with probiotics (Bifidobacterium longum) versus dulaglutide alone in patients with type 2 diabetes:
-1.06%
HbA1c (combo)
vs -0.35% alone
-43.6%
TNF-α reduction
vs -33.3% alone
+34.7%
Beta-cell function
vs +23.1% alone
↑
Beneficial gut
microbiota
Conclusion: "Combining dulaglutide with probiotics enhances glycemic control, reduces inflammation, and improves cardiovascular risk factors... more effectively than dulaglutide alone, likely through gut microbiota modulation."
Opportunity
Probiotic and prebiotic formulations designed as GLP-1 medication companions, with clinical substantiation for enhanced efficacy. This positions supplements not as alternatives but as synergistic adjuncts to prescription therapy.
| Phase | Timeline | Primary Concerns | Search Signal | Product Opportunities |
|---|---|---|---|---|
| Initiation | Days 1-14 | Nausea, adjustment | "side effects" +1,258% | Digestive support, anti-nausea |
| Titration | Weeks 2-8 | GI symptoms, constipation | "is glp 1 safe" +5,592% | Fiber, probiotics, electrolytes |
| Transformation | Months 2-6 | Muscle loss, hair loss | "hair loss" +10,700% | Protein, collagen, hair support |
| Maintenance | Months 6+ | Dose reduction, cost | "without insurance" +60,400% | Natural GLP-1 boosters |
| Discontinuation | Variable | Weight regain | "microdosing" +54,900% | Metabolic support, appetite regulation |
A consistent theme across user communities: outcomes correlate with quality of medical guidance.
"I'm on GLP-1s and my doctor has me eating high protein diet and doing strength training three times a week to prevent muscle loss. I'm lucky that I have a physician that cares, follows the research, and tries to ensure patients are set up for success nutritionally before prescribing these drugs."
"I saw her weekly for 12 weeks, and met with her dietitian from the Cleveland Clinic. My doctor gave me strict instructions: I needed to drink at least 80 ounces of water every day, significantly increase my protein, and weight resistance training was absolutely required."
"Getting them compounded through various websites makes me feel a little twitchy—I really believe that doctors need to follow you closely while taking them."
The Gap
Many users do not receive comprehensive nutritional and lifestyle guidance. Expert consensus explicitly calls for "comprehensive treatment programs" but acknowledges this is often not delivered.
The Opportunity
Educational content and protocols that supplement companies can provide—positioning products within evidence-based frameworks for protein intake, resistance training, and supportive supplementation.
The GLP-1 medication class has transformed weight management. Millions of users are now on a predictable journey with well-documented challenges at specific phases. The search data quantifies their needs. The clinical literature validates those needs. And the supplement industry is positioned to serve them.
The Key Insight
This is not about positioning supplements as alternatives to GLP-1 medications (though that market exists). The larger, more defensible opportunity is positioning supplements as companions to the medication journey—solving real problems that the medications create or don't address:
GI distress
of titration
Muscle loss
of rapid weight reduction
Hair thinning
of telogen effluvium
Protein deficit
of suppressed appetite
Metabolic support
for maintenance
The search behavior shows millions of people actively looking for solutions. The clinical literature shows which problems are substantiated. The user testimonials show what people actually struggle with day-to-day.
For supplement and ingredient companies, the question is not whether this market exists—the data proves it does. The question is whether you'll develop the products and positioning to capture it.